Anti-ZIP-6

Application

Research CategoryApoptosis & Cancer

Anti-ZIP-6 Antibody detects level of ZIP-6 & has been published & validated for use in ZIP-6.

Research Sub CategoryApoptosis - Additional

Immunohistochemistry Analysis: 5 µg/mL from a representative lot detected Anti-ZIP-6 in mouse lung tissue.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Zinc transporter ZIP6, also known as Estrogen-regulated protein LIV-1 or Solute carrier family 39 member 6 orZrt- and Irt-like protein 6 (ZIP-6), and encoded by the gene name ZIP6 or SLC39A6 or LIV1 is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP-6 was initially identified as LIV-1, an estrogen-regulated gene that has been implicated in metastatic breast cancer. Elevated ZIP-6 expression has also been reported in human cervical cancer and the HeLa cell line; down-regulation of ZIP-6 expression in HeLa by RNAi inhibited cell proliferation, colony formation, migration and invasiveness, as well as decreasing Snail and Slug levels, suggesting ZIP-6 plays a regulatory role on the ERK1/2-Snail/Slug pathway.

Immunogen

KLH-conjugated synthetic peptide corresponding to the center region of human Anti-ZIP-6.

Epitope: center region

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Quality

Evaluated by Western Blotting in mouse lung tissue lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected Anti-ZIP-6 in mouse lung tissue lysate.

Specificity

This antibody is recognizes isoforms at ~48 and ~85 kDa and is predicted to not cross-react with other ZIP family members.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Target description

~48 and ~85 kDa observed. Uncharacterized bands may be observed in some lysate(s). Uniprot describes 2 isoforms produced by alternative splicing at ~49 kDa and ~85 kDa