Anti-Glucagon-Like Peptide 1 Receptor

Application

Research Sub CategoryLipid Metabolism & Weight RegulationLipid Signaling

This Anti-GLP1R Antibody is validated for use in Immunohistochemistry (Paraffin) for the detection of GLP1R.

Research CategoryMetabolismSignaling

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Glucagon-Like Peptide 1 Receptor (GLP-1R) is the receptor for glucagon-like peptide 1 and is expressed in the pancreatic beta cells. Ligand binding activates adenyl-cyclase activity which results in increased insulin synthesis and release. GLP-1R is also expressed in the brain where it functions in the control of appetite, memory and learning. GLP-1R also has neuroprotective functions which may be beneficial in diseases such as Huntington′s disease, and drugs that are GLP-1R agonists (acts like natural ligand to activate the receptor) such as Exendin-4 are being examined as potential therapies for the disease as well as diabetes and other memory and metabolic disorders.

Immunogen

KLH-conjugated linear peptide corresponding to the extracellular domain of Human Glucagon-Like Peptide 1 Receptor.

Epitope: extracellular domain, near N-Terminus

Linkage

Replaces: AB9433

Other Notes

Concentration: Please refer to lot specific datasheet.

Physical form

Purified rabbit Polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Antigen Affinity Purified

Quality

Evaluated by Immunohistochemistry (Paraffin) on endocrine cells in human pancreas.

Immunohistochemistry Analysis: 2 ug/ml this antibody showed cytoplasmic staining of subsets of endocrine cells in islets of Langerhans in human pancreas.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Target description

53 kDa calculated