SURVIVIN; RBX -100UL

Application

This Anti-Survivin Antibody is validated for use in WB, IP, IH for the detection of Survivin.

Immunoblotting: Recommended antibody dilution 1:3000-6000

Immunoprecipitation: Recommended antibody dilution 1:200

Immunohistochemisty: Recommended antibody dilution 1:1500

Optimal antibody dilutions must be determined by end-user.

General description

Apoptosis is triggered by a variety of stimuli, including members of the Tumor Necrosis Factor (TNF) family, and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. One of these IAP proteins, Survivin/TIAP, interacts with the processed form of caspase-3 and has been shown to inhibit its proteolytic activity. Survivin/TIAP is predominantly expressed in tissues of embryos, transformed cell lines, and many human cancers and lymphomas.

Immunogen

Recombinant, GST-tagged full length human Survivin

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Physical form

Serum with no preservatives

Storage and Stability

Maintain at -20°C for up to 6 months after date of receipt.