SUBSTANCE P; RB X-100UL

Analysis Note

ControlSpinal Cord.

Application

Research Sub CategoryNeuroinflammation & Pain

Research CategoryNeuroscience

This Anti-Substance P Antibody, pain is validated for use in IH(P), RIA for the detection of Substance P.

RIA:
1:10,000 dilution from a previous lot was used in radioimmunioassay. 80% binding detects at least 5 pg/mL.

Optimal working dilutions must be determined by the end user.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Substance P is a tachykinin family neuropeptide that functions as a neurotransmitter and neuromodulator. In the CNS, Substance P is involved in the regulation of mood, anxiety, sleep, saiety, reinforcement, respiratory rhythm and pain processing. In nociception, the neuropeptide is released at local spinal cord synapse. Recent research now shows substance P is potentially involved in endothelial cell differentiation as well as diverse roles in neuroinflammatory response. The endogenous receptor for Substance P is neurokinin 1 receptor (NK1 receptor), which belongs to the tachykinin receptor sub-family of GPCRs.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Rabbit polyclonal serum containing 0.1% sodium azide.

Unpurified

Quality

Immunohistochemistry(paraffin):
Substance P (AB1566) representative staining pattern/morphology in Alzheimer’s brain. Tissue pretreated with Citrate pH6.0, antigen retrieval. Antibody diluted to 1:100.
IHC-Paraffin Staining With Citrate pH 6.0 Epitope Retrieval: Alzheimer’s Brain.

Specificity

Substance P

Storage and Stability

Stable for 1 year at -20°C from date of receipt.