Prion Protein, His#Tag�, Hum 1PC X 100UG

General description

Recombinant, human prion protein (amino acids 23-231) fused to a His Tag™ sequence and expressed in E. coli. Useful as an antigen standard in immunochemical detection of Creutzfeldt-Jakob Disease (CJD).

Recombinant, human prion protein (amino acids 23-231) fused to a His Tag™ sequence and expressed in E. coli. Prion diseases or transmissible spongiform encephalopathies are neurodegenerative diseases that affect both humans and animals. All prion diseases share the same molecular pathogenic mechanism that involves conversion of normal cellular prion protein (PrPc) into a form that is insoluble in non-ionic detergent and partially resistant to proteases (PrPsc). Useful as an antigen standard in immunochemical detection of Creutzfeldt-Jakob Disease (CJD).

Legal Information

HIS TAG is a registered trademark of Merck KGaA, Darmstadt, Germany

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Calzolai, L., and Zahn, R. 2003. J. Biol. Chem.278, 35592.Prusiner, S.B. 1998. Proc. Natl. Acad. Sci. USA95, 13363.Swietnicki, W., et al. 1997. J. Biol. Chem.272, 27517.Pan, K.M., et al. 1993. Proc. Natl. Acad. Sci. USA90, 10962.Basler, K., et al. 1986. Cell46, 417.

Packaging

100 µg in Plastic ampoule

Physical form

In 10 mM sodium acetate, pH 4.0.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C).

Warning

Toxicity: Standard Handling (A)