General description

Predominant peptide found in the brain of patients with Alzheimer's Disease and Down's Syndrome. Promotes down-regulation of Bcl-2 and upregulation of Bax expression in neurons.

β-Amyloid Peptide (Aβ) is the main constituent in both senile plaques and diffuse deposits in Alzheimer′s diseased brains. Under appropriate conditions, the soluble amyloid peptides aggregate into the fibrils associated with the disease state. It has proposed that Aβ peptide may increase the sensitivity of neurons to oxidative damage by downregulating expression of bcl-2, a key anti-apoptotic protein and upregulating of bax expression, a protein known to induce cell death.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Paradis, E., et al. 1996. J. Neurosci.16, 7533.Roher, A.E., et al. 1996. J. Biol. Chem.271, 20631.Soto, C., and Castano, E.M. 1996. Biochem. J.314, 701.Murrell, J., et al. 1991. Science254, 97.Goldgaber, D., et al. 1987. Science235, 877.Kang, J., et al. 1987. Nature 325, 733.

Packaging

250 µg in Plastic ampoule

Sequence

H-Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH

Warning

Toxicity: Standard Handling (A)