14-924 Display Image

TYK2; active 10ug

Code: 14-924 D2-231


Research CategorySignaling

Biochem/physiol Actions

Target Sub-Family: TK

Protein Target: TYK2


read more

Your Price
€485.51 EACH
€597.18 inc. VAT


Research CategorySignaling

Biochem/physiol Actions

Target Sub-Family: TK

Protein Target: TYK2


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

TYK2 is member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.

Product Source: N-terminal 6His-tagged, recombinant, human TYK2 amino acids 875-end, expressed by baculovirus in Sf21 insect cells.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.


Also available in 250µg size as catalog # 14-924M and in bulk as catalog # 14-924-K.

Physical form

Purified using immobilized metal affinity chromatography followed by gel filtration.

50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol


Routinely evaluated by phosphorylation of peptide GGMEDIYFEFMGGKKK

Storage and Stability

6 months at -70°C

biological sourcehuman
mol wtMw 40 kDa
NCBI accession no.NM_003331
Quality Level300, 100
recombinantexpressed in baculovirus infected Sf21 cells
technique(s)activity assay: suitable (kinase)
UniProt accession no.P29597
This product has met the following criteria: