p38a/SAPK2a(T106M);active 10ug

Code: 14-687 D2-231

General description

N-terminal GST-tagged, recombinant, human, full-length p38α/SAPK2a containing the mutation T106M. Activated using DD-MKK6 (14-537) and repurified usi...


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General description

N-terminal GST-tagged, recombinant, human, full-length p38α/SAPK2a containing the mutation T106M. Activated using DD-MKK6 (14-537) and repurified using glutathione- agarose.

Contains the gatekeeper mutation T160M in the ATP-binding domain. This mutation increases resistance to SB203580 as compared to the wild type sequence.

Product Source: Human, full-length p38α/SAPK2a containing the mutation T106M. Expressed in E. coli.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Quality

routinely evaluated by phosphorylation of MBP (13-104).

biological sourcehuman
Gene Informationhuman ... MAPK14(1432)
manufacturer/tradenameUpstate®
mol wtMw 67.7 kDa
NCBI accession no.NM_139014.1, NM_139013.1, NM_139012.1, NM_001315.1
Quality Level300, 100
recombinantexpressed in E. coli
technique(s)activity assay: suitable (kinase)
UniProt accession no.Q16539
This product has met the following criteria to qualify for the following awards:



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