Analysis Note

ControlHuman kidney tissue.

Application

Research CategorySignaling

Research Sub CategoryInsulin/Energy Signaling

Anti-GLUT-8 Antibody, C-terminus detects level of GLUT-8 & has been published & validated for use in IH(P).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

GLUT-8 is a glucose transporter facilitated by the regulation of insulin, binding cytochalasin B such that the orientation is glucose-inhibitive. In appearance, the transporter seems to be a dual-specific sugar transporter since fructose can also be inhibitive. GLUT-8 is expressed largely in the testis, where down-regulation is facilitated by estrogen. However, GLUT-8 is not highly expressed in testicular carcinoma. Lower levels of GLUT-8 are present in most other tissues.

Immunogen

Epitope: C-terminus

An 11 amino acid sequence near the C-terminus of mouse Glut-8 (Doege et al. 2000; Carayannopoulos et al. 2000)

Linkage

Replaces: AB3140

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

ImmunoAffinity Purified

Format: Purified

Liquid in PBS with 0.1% BSA.

Quality

Evaluated by Immunohistochemistry in human kidney tissue
Immunohistochemistry Analysis: 1:100 dilution of this lot detected GLUT-8 in human kidney tissue.

Specificity

Recognizes GLUT-8.

Storage and Stability

Maintain at -20°C in undiluted aliquots for up to 1 year from date of receipt. Avoid repeated freeze/thaw cycles.

Target description

Approx. 50 kDa