A HU P27 KIP 1 PC 12-309

Code: 06-445 D2-231

Application

Anti-Kip1 (p27) Antibody is a high quality Rabbit Polyclonal Antibody for the detection of Kip1 (p27) & has been validated in IHC, IP & WB.

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€429.00 EACH
€527.67 inc. VAT

Application

Anti-Kip1 (p27) Antibody is a high quality Rabbit Polyclonal Antibody for the detection of Kip1 (p27) & has been validated in IHC, IP & WB.

General description

p27(Kip1) is a cyclin-dependent kinase inhibitor involved in G1 arrest. p27(Kip1) binds to and inhibits cyclinE-Cdk2 complex, cyclinA-CDK2 and cyclinD1-CDK4. p27(Kip1) is regulated by phosphorylation on serine 10 (S10) and threonine 187 (T187). Phosphorylation by CDK2 on T187 results in ubiquitylation and degradation of p27(Kip1); while phosphorylation by hKIS on S10 signals the nuclear export to the cytoplasm.

Immunogen

An 18 amino acid synthetic peptide ([C]GSVEQTPKKPGLRRRQT) linked to KLH was used to immunize rabbits

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Linkage

Replaces: 04-240

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Format: Purified

Quality

routinely evaluated by immunoblot on HeLa nuclear extract or in rabbit brain nuclear extract

Specificity

Recognizes Kip1.

Target description

27 kDa

antibody formpurified immunoglobulin
antibody product typeprimary antibodies
biological sourcerabbit
clonepolyclonal
Gene Informationhuman ... CDKN1B(1027)
isotypeIgG
manufacturer/tradenameUpstate®
NCBI accession no.NM_004064
packagingantibody small pack of 25 µg
Quality Level100
shipped indry ice
species reactivityhuman, rabbit, rat
technique(s)western blot: suitable, immunoprecipitation (IP): suitable, immunohistochemistry: suitable
UniProt accession no.P46527
This product has met the following criteria to qualify for the following awards:



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