Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Primary TargetHomeostatic control of Ca2+ and phosphate metabolism

General description

N-terminal active peptide fragment of the native hormone that functions as a regulatory factor in the homeostatic control of Ca²⁺ and phosphate metabolism. Regulates Ca²⁺ and phosphate flux across cellular membranes in bone and kidney, resulting in increased serum Ca²⁺ levels. Increases the activity of osteoblasts and osteoclasts. Increases tubular reabsorption of Ca²⁺ and stimulates renal hydroxylation of 25-(OH)-Vitamin D₃ to 1,25-(OH)₂-Vitamin D₃. Increases the production of inhibitory IGF binding protein 4 in bone cells.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Matsui, H., et al. 1995. Am. J. Physiol.268, R21.Dua, K., et al. 1994. Exp. Physiol.79, 401.

Packaging

Yes

Physical form

Supplied as an trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sequence

H-Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-OH

Warning

Toxicity: Standard Handling (A)