Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Primary TargetStimulator of interleukin-6 production by endothelial cell lines

General description

Attenuates thrombin-evoked aggregation of human platelets. A potent stimulator of interleukin-6 production by endothelial cell lines. Reported to activate phospholipase C in fibroblasts expressing ET_A receptors.

Attenuates thrombin-evoked aggregation of human platelets. A potent stimulator of interleukin-6 production by endothelial cell lines. Reported to activate phopholipase C in fibroblasts expressing ET_A receptors.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Gresser, O., et al. 1996. Biochem. Biophys. Res. Commun.224, 169.Astarie-Dequeker, C., et al. 1995. Br. J. Pharmacol. 114, 524.Xin, X., et al. 1995. Endocrinology 136, 132.Brunner, F., et al. 1992. J. Mol. Cell. Cardiol.24, 1291.Lamers, J.M., et al. 1992. Mol. Cell. Biochem. 116, 59.

Packaging

Yes

Physical form

Supplied as a trifluoroacetate salt. Sold on the basis of peptide content.

Preparation Note

Dissolve peptide initially at 8 mg/ml in 80% cold acetic acid, then dilute with cold water to 5% acetic acid and 0.5 mg/ml peptide.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Sequence

H-Cys¹-Thr-Cys³-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys¹¹-Val-Tyr-Tyr-Cys¹⁵-His-Leu-Asp-Ile-Ile-Trp-OH (disulfide bonds: 1 → 15; 3 → 11)