05-23-3800-0.1MG Display Image

ENDOTHELIN 1, HUMAN AND PORC 1PC x 0.1MG

Code: 05-23-3800-0.1MG D2-231

Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Primary TargetPotent vasoconstrictive action

Gene...


read more

Your Price
€189.45 EACH

Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Primary TargetPotent vasoconstrictive action

General description

A 21 amino acid polypeptide with potent vasoconstrictive action. Produces convulsions, arterial hypertension, and metabolic activation of periventricular white and gray matter. Its effects are mediated via L-type Ca2+ channels. Reported to activate phospholipase C in fibroblasts expressing ETA receptors.

A 21-amino acid polypeptide with potent vasoconstrictive action. Produces convulsions, arterial hypertension, and metabolic activation of periventricular white and gray matter. Its effects are mediated via L-type Ca2+ channels. Reported to activate phospholipase C in fibroblasts expressing ETA receptors.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Cesari, M., et al. 1996. Am. Heart J.132, 1236.Gresser, O., et al 1996. Biochem. Biophys. Res. Commun.224, 169.Murata, S., et al. 1995. J. Pharmacol. Exp. Ther. 274, 1524.Hexum, T.D., et al. 1990. Biochem. Biophys. Res. Commun. 167, 294.Itoh, Y., et al. 1988. FEBS Lett. 231, 440.Yanagisawa, M., et al. 1988. Nature 332, 411.

Packaging

Yes

Physical form

Supplied as an acetate salt.

Preparation Note

Dissolve peptide initially at 8 mg/ml in 80% cold acetic acid, then dilute with distilled water to achieve 5% acetic acid and 0.5 mg/ml peptide.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.

Sequence

H-Cys¹-Ser-Cys³-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys¹¹-Val-Tyr-Phe-Cys¹⁵-His-Leu-Asp-Ile-Ile-Trp-OH (disulfide bonds: 1 → 15; 3 → 11)

Warning

Toxicity: Standard Handling (A)

assay≥96% (HPLC)
colorwhite to off-white
formsolid
InChI keyZUBDGKVDJUIMQQ-UHFFFAOYSA-N
InChI1S/C109H159N25O32S5/c1-12-56(9)87(107(163)125-76(109(165)166)39-60-43-113-65-24-18-17-23-63(60)65)134-108(164)88(57(10)13-2)133-99(155)75(42-85(143)144)123-94(150)70(36-54(5)6)118-97(153)73(40-61-44-112-52-114-61)121-103(159)80-49-169-168-48-64(111)89(145)126-77(45-135)102(158)131-81-50-170-171-51-82(105(161)132-86(55(7)8)106(162)124-72(38-59-26-28-62(138)29-27-59)95(151)120-71(96(152)130-80)37-58-21-15-14-16-22-58)129-91(147)67(30-31-83(139)140)116-90(146)66(25-19-20-33-110)115-98(154)74(41-84(141)142)122-92(148)68(32-34-167-11)117-93(149)69(35-53(3)4)119-100(156)78(46-136)127-101(157)79(47-137)128-104(81)160/h14-18,21-24,26-29,43-44,52-57,64,66-82,86-88,113,135-138H,12-13,19-20,25,30-42,45-51,110-111H2,1-11H3,(H,112,114)(H,115,154)(H,116,146)(H,117,149)(H,118,153)(H,119,156)(H,120,151)(H,121,159)(H,122,148)(H,123,150)(H,124,162)(H,125,163)(H,126,145)(H,127,157)(H,128,160)(H,129,147)(H,130,152)(H,131,158)(H,132,161)(H,133,155)(H,134,164)(H,139,140)(H,141,142)(H,143,144)(H,165,166)
manufacturer/tradenameCalbiochem®
Quality Level100
shipped inambient
solubility5% acetic acid: 0.5 mg/mL
storage conditiondesiccated, OK to freeze
storage temp.−20°C
Code
Description
Unit Size
List Price
Qty
05-23-3800-0.5MG
Unit:EACH
List Price: €633.55
Source:List Price
ADD
05-23-3800-1MG
Unit:EACH
List Price: €1,003.11
Source:List Price
ADD
Cas Number117399-94-7
This product has met the following criteria:



Quantity
Est. Dispatch/Availability