HiTrap MabSelect SuRe, Cytiva, 29-0491-04, pack of 1 mL

Code: GE29-0491-04 D2-231

Features and Benefits

Withstands rigorous CIP and sanitization procedures with 0.1 to 0.5 M NaOH. Novel ligand design gives enhanced protease resistance resulting in lower li...


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Features and Benefits

Withstands rigorous CIP and sanitization procedures with 0.1 to 0.5 M NaOH. Novel ligand design gives enhanced protease resistance resulting in lower ligand leakage. Oriented coupling of recombinant Protein A to the matrix via an engineered C-terminal cysteine enhances IgG binding capacity. Fewer regulatory concerns due to the total absence of mammalian culture in the ligand production and purification. Prepacked HiTrap columns for process development, screening of purification conditions, and small-scale purification of Mabs.

General description

HiTrap MabSelect SuRe columns are prepacked with MabSelect SuRe, a BioProcess medium for purification of monoclonal antibodies from large sample volumes. The novel alkali-tolerant recombinant Protein A ligand allows cleaning-in-place (CIP).

Legal Information

MabSelect SuRe is a trademark of Cytiva

Free MabSelect SuRe Ligand"MabSelect SuRe Ligand Restricted License" and "Cys-rProtein A Ligand Restricted License" are protected by the following patents and equivalent patents and patent applications in other countries: US 6,399,750 and EP 1123389. A free, non-transferable limited license to use this product for internal analytical purposes only accompanies the purchase of the product from a Cytiva company and its licensed distributors. Any other use will require a separate license from a Cytiva company.

HiTrap is a registered trademark of Cytiva

availabilitynot available in North America
avg. part. size85 µm (d??v is the median particle size of the cumulative volume distribution)
bed size7 mm × 25 mm
bed volume1 mL
capacity≥30 mg binding capacity (humanlgG/ml at 2.4 min residence time)(Determined at 10% breakthrough by frontal analysis at a mobile phase velocity of 500 cm/h in a column with a bed height of 20 cm.)
cleaning2-13.7(pH below 3 is sometimes required to elute strongly bound IgG species. However, protein ligands may hydrolyze at very low pH.)
column I.D.7 mm
manufacturer/tradenameCytiva 29-0491-04
matrixhighly cross-linked agarose
packagingpack of 1 mL
parameter﹤4 mL/min flow rate (The pressure over the packed bed varies depending on a range of parameters such as the characteristics of the chromatography medium and the column tubing used.), 42 psi
shelf lifePlease be aware this product may be shipped 90 days before the expiration date. For more information on the batch specific expiration date, please contact technical service.
storage condition(20% Ethanol), (20% Ethanol, 0.1 M Potassium Phosphate buffer, pH 8.0)
storage temp.2-8°C
suitabilitysuitable for bioprocess medium
working range3-12(pH below 3 is sometimes required to elute strongly bound IgG species. However, protein ligands may hydrolyze at very low pH.)
Hazard Class3
Un Number1170
Pack GroupIII
This product has met the following criteria to qualify for the following awards:



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