POSACONAZOLE

Code: SML2287-25MG D2-231

Application

Posaconazole has been used:in antifungal susceptibility testing of Aspergillus terreusas a lanosterol14α-demethylase (CYP51)-specific inhibitor to study ...


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€514.49 25MG
€632.82 inc. VAT
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Application

Posaconazole has been used:in antifungal susceptibility testing of Aspergillus terreusas a lanosterol14α-demethylase (CYP51)-specific inhibitor to study its effects on membrane permeability in Candida albicans cellsto study its effects on promastigotes

Biochem/physiol Actions

Posaconazole is a highly potent broadspectrum antifungal agent against the yeast infection caused especially by Candida sp. It blocks the growth of fungi by inhibiting the enzymelanosterol14α-demethylase (CYP51). In contrast to other antifungal azoles, posaconazole has been reported not to induce the efflux pump mechanism. Posaconazole exhibits antichagasic effects against different strains of Trypanosoma cruzi causing Chagas disease.

assay≥98% (HPLC)
colorwhite to beige
formpowder
InChI keyRAGOYPUPXAKGKH-XAKZXMRKSA-N
InChI1S/C37H42F2N8O4/c1-3-35(26(2)48)47-36(49)46(25-42-47)31-7-5-29(6-8-31)43-14-16-44(17-15-43)30-9-11-32(12-10-30)50-20-27-19-37(51-21-27,22-45-24-40-23-41-45)33-13-4-28(38)18-34(33)39/h4-13,18,23-27,35,48H,3,14-17,19-22H2,1-2H3/t26-,27+,35-,37-/m0/s1
optical activity[α]/D -24 to -32°, c = 1.0 in chloroform-d
solubilityDMSO: 2 mg/mL, clear
storage temp.−20°C
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