Biochem/physiol Actions

Nexinhib20 prevents the expression of cytochromeb558in the plasma membrane. It modulates vesicular trafficking and neutrophil activities. Nexinhib20 reduces the systemic inflammation, mediated by neutrophils.

Nexinhib20 (neutrophil exocytosis inhibitor 20) is a potent inhibitor of the interaction between the small GTPase Rab27a and its effector JFC1 (synaptotagmin-like protein1). Nexinhib20 inhibits exocytosis of azurophilic granules in human neutrophils without affecting other important innate immune responses including phagocytosis and neutrophil extracellular trap production.