AS8351

Code: SML1692-5MG D2-231

Biochem/physiol Actions

AS8351 is an iron chelator that has been found to inhibit of histone demethylase KDM5B (JARID1B), a histone H3K4 demethylase involved in regulation of...


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€131.50 5MG
€161.75 inc. VAT
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Biochem/physiol Actions

AS8351 is an iron chelator that has been found to inhibit of histone demethylase KDM5B (JARID1B), a histone H3K4 demethylase involved in regulation of cell proliferation and stem cell self-renewal and differentiation. AS8351 is thought to inhibit KDM5B by competing with a-ketoglutarate for chelating iron that KDM5B requires as a co-factor.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
colorwhite to beige
formpowder
InChI keyWQSHHAVECQJKLX-YBFXNURJSA-N
InChI1S/C17H13N3O2/c21-16-6-5-12-3-1-2-4-14(12)15(16)11-19-20-17(22)13-7-9-18-10-8-13/h1-11,21H,(H,20,22)/b19-11+
Quality Level100
SMILES stringOC1=CC=C(C=CC=C2)C2=C1/C=N/NC(C3=CC=NC=C3)=O
solubilityDMSO: 20 mg/mL, clear
storage conditiondesiccated
storage temp.−20°C
Cas Number796-42-9
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