Application

NMDI14 has been used as a nonsense-mediated mRNA decay (NMD) inhibitor:to study its effects on differentiating cardiomyocytesto study its effects on zebrafish pdzk1 gene-knockout embryosto analyze its effects on the apoptosis of colorectal cancer cells

Biochem/physiol Actions

NMDI14 is a potent nonsense-mediated RNA decay (NMD) inhibitor. NMDI14 targets a pocket in the SMG7 protein and disrupts SMG7–UPF1 interactions. NMDI14 restores of full-length p53 protein activity in in cells with premature termination codons (PTC) mutated p53.

Packaging

5, 25 mg in glass bottle