SW033291

Code: SML1485-5MG D2-231

Biochem/physiol Actions

SW033291 is an inhibitor of the prostaglandin-degrading enzyme 15-PGDH. PGE2 is known to promote hematopoiesis and to promote reeneration by causing s...


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€218.50 5MG
€268.76 inc. VAT
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Biochem/physiol Actions

SW033291 is an inhibitor of the prostaglandin-degrading enzyme 15-PGDH. PGE2 is known to promote hematopoiesis and to promote reeneration by causing stem cells to proliferate. 15-PGDH degrades prostaglandin PGE2 and is a negative regulator of tissue regeneration and repair. SW033291 inhibition of 15-PGDH doubled levels of PGE2 and doubled rates of colon and liver tissue regeneration. Mice given SW033291 after receiving a bone marrow transplant had a two- to threefold increase in the number of donor cells that homed to the their bone marrow.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
colorlight yellow to yellow-green
formpowder
InChI keyLCYAYKSMOVLVRL-UHFFFAOYSA-N
InChI1S/C21H20N2OS3/c1-2-3-12-27(24)21-19(22)18-15(14-8-5-4-6-9-14)13-16(23-20(18)26-21)17-10-7-11-25-17/h4-11,13H,2-3,12,22H2,1H3
Quality Level100
SMILES stringNC1=C(S(CCCC)=O)SC2=NC(C3=CC=CS3)=CC(C4=CC=CC=C4)=C21
solubilityDMSO: 5 mg/mL, clear (warmed)
storage temp.2-8°C
Cas Number459147-39-8
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