NQ301

Code: SML1337-5MG D2-231

Biochem/physiol Actions

NQ301 is an antithrombotic agent. Recent study shows that NQ301 (Compound 211) is a highly potent, selective, non-competitive allosteric inhibitor of ...


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€106.70 5MG
€131.24 inc. VAT
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Biochem/physiol Actions

NQ301 is an antithrombotic agent. Recent study shows that NQ301 (Compound 211) is a highly potent, selective, non-competitive allosteric inhibitor of CD45 that selectively inhibits dephosphorylation of substrate Lck pY-505 versus Lck pY-393. NQ301 prevents T cell receptor-mediated activation of Lck, Zap-70 and MAPK, and IL-2 production in primary T-cells. NQ301 exhibits immunosuppressive activity in mice.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
color, faint red to dark red
formpowder
InChI keyLSQZKIQSQHZVQS-UHFFFAOYSA-N
InChI1S/C18H12ClNO3/c1-10(21)11-6-8-12(9-7-11)20-16-15(19)17(22)13-4-2-3-5-14(13)18(16)23/h2-9,20H,1H3
Quality Level100
SMILES stringO=C1C(Cl)=C(NC2=CC=C(C(C)=O)C=C2)C(C3=CC=CC=C31)=O
solubilityDMSO: 10 mg/mL, clear
storage temp.2-8°C
Cas Number130089-98-4
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