Application

Pitstop 2 has been used as an inhibitor of clathrin-mediated endocytosis.

Biochem/physiol Actions

Pitstop 2 is a selective inhibitor of clathrin-mediated endocytosis.

Pitstop 2 also has an ability to breakdown the nuclear pore complex (NPC) permeability barrier and decrease importin β binding along with alteration of the NPC ultrastructure. Pitstop 2 is also involved in the inhibition of platelet activation, platelet aggregation and secretion.

Pitstop 2 is a selective inhibitor of clathrin-mediated endocytosis that acts via blocking ligand access to the clathrin terminal domain. Pitstop 2 selectively inhibits clathrin-mediated HIV entry and stalls clathrin-coated pit (CCP) dynamics.

Packaging

5, 25 mg in glass bottle