Application

NBD Sphingosine or omega(7-nitro-2-1,3-benzoxadiazol-4-yl)(2S,3R,4E)-2-aminooctadec-4-ene-1,3-diol may be used:as a negative control to determine the binding of Atg12-Atg5 conjugate with phosphatidylethanolamine (PE)-containing liposomesto label sphingosine kinase 1 (SphK1) in order to determine its role in endocytic membrane traffickingto generate 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD)-ceramide C16

Biochem/physiol Actions

Sphingosine serves as a precursor for ceramide. It is involved in the inhibition of protein kinase C in human platelets.

General description

Sphingosine is the most bioactive sphingoid with the common long chain base in sphingolipids. It is a constituent of the cell membrane. 7-nitro-2-1,3-benzoxadiazol-4-yl (NBD) sphingosine is a derivative of sphingosine attached with the fluorescent probe, NBD group.

Packaging

5 mL Amber Glass Screw Cap Vial (810205X-250ug)