Application

Coag Reagent I has been used in the preparation of small unilamellar vesicles (SUVs) for α-synuclein binding studies. It may be used in the preparation of bilayers for reconstituting ryanodine receptor type 2 (RyR2) for single-channel recording studies. It may be used for glass supported lipid bilayers preparation.

Biochem/physiol Actions

Coag Reagent I mixed lipid is useful in the preparation of supported lipid bilayers and platelet membranes for coagulation studies. It is used in the small unilamellar vesicles (SUVs) generation for α-synuclein and squalamine binding studies.

General description

Coag Reagent I comprises 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine(DOPE), 1,2-dioleoyl-sn-glycero-3-phospho-L-serine (DOPS) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) in the ratio 5:3:2 w/w. They are present predominantly in the synaptic vesicle membrane. DOPC has choline group and DOPE comprises ethanolamine moiety. At neutral pH, DOPE and DOPC exist as a zwitterion whereas DOPS takes up a negative charge and has a serine group.

Packaging

5 mL Clear Glass Sealed Ampule (790304P-200mg)

5 mL Clear Glass Sealed Ampule (790304P-25mg)