Application

Cholesteryl phosphocholine has been used in the preparation of multilamellar lipid vesicles (MLVs) for nuclear magnetic resonance (NMR) and differential scanning calorimetry (DSC) studies. It has also been used in the preparation of ceramide-cholesterol phosphocholine bilayers.

Biochem/physiol Actions

Cholesteryl phosphocholine (CholPC) is used in the generation of stable lipid bilayers. CholPC complexed to C6-ceramide is bioavailable and is useful in cell culture delivery studies. The CholPC and ceramide mixture is stable.

General description

Ceramide forms stable, fluid bilayers with cholesteryl phosphocholine, and this formulation has been shown to be more potent than solvent-delivered (DMSO) formulations of C6 Ceramide in inhibiting proliferation, inducing apoptosis, and disturbing calcium homeostasis.CholPC forms bilayers (giant uni- and multilamellar vesicles, as well as extruded large unilamellar vesicles) with both ceramides and cholesterol. The extruded bilayers appear to be fluid, although highly ordered, even when the ceramide has an N-linked palmitoyl acyl chain.

Cholesteryl phosphocholine (CholPC) structure has hydrophobic region and a large polar head group. It takes up an umbrella structure upon interaction with lipids.

Packaging

5 mL Amber Glass Screw Cap Vial (700123P-25mg)

20 mL Clear Glass Screw Cap Vial (700123P-500mg)