Application

3-oxo-4-cholestenoic acid has been used as a inducer ligand for the TetR-like repressor (KstR) of M. smegmatis.

Biochem/physiol Actions

3-oxo-4-cholestenoic acid (3OChA) acts as an inducer to the TetR-like repressor (KstR) and modulates the expression kstR regulon genes.

General description

3-oxo-4-cholestenoic acid (3OChA) is synthesized from cholesterol by the oxidation at the positions C3 and C26 in the presence of P450 cytochromes (CYP125 and CYP142). This pathway is well established in M. smegmatis. 3OChA is an intermediate in cholesterol catabolism and is more soluble compared to cholesterol.

Packaging

5 mL Amber Glass Screw Cap Vial (700083P-1mg)