Application

24(S)-hydroxycholesterol has been used as an internal standard: in ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS)in liquid chromatography with tandem mass spectrometry (LC-MS/MS) for the quantification of 27-hydroxycholesterol from colorectal tumor samplesfor quantification of human plasma sterols by liquid chromatography with tandem mass spectrometry (LC MS/MS)

Biochem/physiol Actions

24(S)-hydroxycholesterol (24HC) elevated levels are reported in liver inflammation and fibrosis. It is a N-methyl-D-aspartate receptor (NMDAR) modulator. The levels of 24HC are potential indicators of brain development as well as pathology including Alzheimer′s disease (AD) and multiple sclerosis. Polymorphism in the cholesterol 24-hydroxylase (CYP46A1) gene leads to elevated 24HC levels and toxicity. 24HC is a mediator of apoptosis and necroptosis. Elevated levels of 24HC are reported in liver inflammation and fibrosis.

General description

24(S)-hydroxycholesterol (24HC) is synthesized from cholesterol in brain dendrites by the action of enzyme cholesterol 24-hydroxylase (CYP46A1). It is catabolized to bile acids in the liver.

Packaging

5 mL Amber Glass Screw Cap Vial (700061P-5mg)

5 mL Amber Glass Screw Cap Vial (700061P-1mg)