Application

7α,27-dihydroxy-4-cholesten-3-one may be used as a ligand to test its effect on Epstein-Barr virus-induced molecule 2 (EB12) activation in guanosine 5′-O-(3-thio)triphosphate ([³⁵S] GTPγS) binding assay.

Biochem/physiol Actions

7α,27-dihydroxy-4-cholesten-3-one is a suppressor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase.

General description

7α,27-dihydroxy-4-cholesten-3-one synthesized by the hydroxylation of 27-hydroxycholesterol in the presence of the enzyme cholesterol 7 α-hydroxylase (CYP7A1) and is catabolized to bile acid. 7α,27-dihydroxy-4-cholesten-3-one is present majorly in fibroblasts and its conversion from cholesterol occurs in extrahepatic tissues.

Packaging

5 mL Amber Glass Screw Cap Vial (700023P-1mg)