General description

A potent competitive inhibitor of cytidine deaminase. Used in combination with cytosine arabinoside (Ara-C) to assess the anti-leukemic activity and anti-tumor activity of Ara-C in in vitro studies.

Potent competitive inhibitor of cytidine deaminase. Also available as a 100 mM solution in H₂O(Cat. No. 584223).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Yusa, K., et al. 1995. Biochem. Biophys. Res. Commun. 206, 486.Bouffard, D.Y., et al. 1993. Biochem Pharmacol.45, 1857.Laliberte, J., et al. 1992. Cancer Chemotherap. Pharmacol.30, 7.Riva, C., et al. 1992. Chemotherapy38, 358. Yusa, K., et al. 1992. J. Biol. Chem. 267, 16848.Hanze, A.R. 1967. J. Am. Chem. Soc.89, 6720.

Packaging

Packaged under inert gas

10 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Aqueous stock solutions (at neutral or basic pH) are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)