General description

Enzymatically prepared tetrasaccharide which acts as a minimal binding ligand for E-selectins. SLe^x reduces injury following ischemia, reperfusion and immune complex-induced acute lung injury in animal models. In both of these models, SLe^x is presumed to act by blocking E-selectin-mediated neutrophil recruitment to sites of inflammation.

Enzymatically prepared tetrasaccharide which acts as a minimal binding ligand for E-selectins. SLe^x reduces injury following ischemia and reperfusion and immune complex-induced acute lung injury in animal models. In both of these models, SLe^x is presumed to act by blocking E-selectin-mediated neutrophil recruitment to sites of inflammation.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Seekamp, A., et al. 1994. Am. J. Pathol.144, 592.Mulligan, M.S., et al. 1993. J. Exp. Med.178, 623.Ichikawa, Y., et al. 1992. J. Am. Chem. Soc. 114, 9283.Lasky, L.A. 1992. Science 258, 964.

Packaging

1, 5 mg in Plastic ampoule

Warning

Toxicity: Standard Handling (A)