Biochem/physiol Actions

Target K_i: 11.9 nM for activating PKCα

Reversible: no

Product does not compete with ATP.

Primary TargetPKC

Cell permeable: yes

General description

A cell-permeable benzolactam derived PKC activator (K_i = 11.9 nM for PKCα) that efficiently enhances non-amyloidogenic α-processing of amyloid precursor protein (APP) even at 100 nM in human fibroblast AG06848. Displays a marked loss of tumor promoting activity.

A cell-permeable PKC activator (K_i = 11.9 nM for PKCα) that efficiently enhances non-amyloidogenic α-processing of amyloid precursor protein (APP) but lacks any tumor promoting activity.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Kozikowski, A.P., et al. 2003. J. Med. Chem.46, 364.

Packaging

1 mg in Plastic ampoule

Packaged under inert gas

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Warning

Toxicity: Standard Handling (A)