Application

InSolution™ Purmorphamine, CAS 483367-10-8, is a provided as a 50 mM solution in DMSO. Induces osteoblast differentiation of multipotent mesenchymal progenitor cells C3H10T1/2 & lineage-committed preosteoblasts MC3T3-E1.

General description

A cell-permeable purine compound that induces osteoblast differentiation in C3H10T1/2 multipotent mesenchymal progenitor cells (EC₅₀ = 1 µM) and in MC3T3-E1 lineage-committed preosteoblasts. Also shown to induce transdifferentiation in pre-adipocytes and myoblasts. Its effects are reported to be synergistic with bone morphogenetic protein-4 (BMP-4). Reported to induce osteogenesis by activation of the Hedgehog signaling pathway.

Purmorphamine is a cell-permeable purine compound that induces osteoblast differentiation in C3H10T1/2 multipotent mesenchymal progenitor cells.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Wu, X., et al. 2004. Chem. Biol.11, 1229.Wu, X., et al. 2002. J. Am. Chem. Soc.124, 14520.

Packaging

Packaged under inert gas

5 mg in Plastic ampoule

Physical form

A 50 mM (5 mg/192 µl) solution of Purmorphamine (Cat. No. 540220) in DMSO.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C).

Warning

Toxicity: Irritant (B)