MG PTP1B Inhibitor 1PC x 5MG

Biochem/physiol Actions

Reversible: yes

Product does not compete with ATP.

Target IC₅₀: 4 µM and 8 µM for PTP1B403 and PTP1B298, respectively

Primary TargetPTP1B403

Cell permeable: yes

General description

A cell-permeable, selective, reversible, and non-competitive allosteric inhibitor of PTP1B (IC₅₀ = 4 µM and 8 µM for PTP1B₄₀₃ and PTP1B₂₉₈, respectively). Binds to a novel site away from the catalytic pocket and inhibits PTP1B activity by preventing closure of the WPD loop. Also available in InSolution™ format (Cat. No. 539749.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Wiesmann, C., et al. 2004. Nat. Struct. Mol. Biol.11, 730.

Packaging

Packaged under inert gas

5 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Warning

Toxicity: Standard Handling (A)