Biochem/physiol Actions

Reversible: yes

Product competes with ATP.

Target IC₅₀: 89 nM against p38 MAP kinase

Primary Targetp38 MAP kinase

Cell permeable: yes

General description

A potent, cell-permeable, reversible, competitive, and selective p38 MAP kinase inhibitor (IC₅₀ = 89 nM). Inhibition of p38 MAP kinase by PD 169316 blocks apoptosis induced by trophic factor withdrawal in non-neuronal and neuronal cell lines.

A potent, cell-permeable, reversible, competitive, and selective p38 MAP kinase inhibitor (IC₅₀= 89 nM). Inhibition of p38 MAP kinase by PD 169316 blocks apoptosis induced by trophic factor withdrawal in non-neuronal and neuronal cell lines.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Nath, R., et al. 2001. Cell Mol. Biol. Lett.6, 173.Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.Kummer, J.L., et al. 1997. J. Biol. Chem. 272, 20490.

Packaging

1 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.

Warning

Toxicity: Standard Handling (A)