CTAP

Biochem/physiol Actions

Primary Targetu Opioid receptpr

General description

A highly potent octapeptide that acts as a selective and brain penetrating bioavailable µ opioid receptor antagonist (IC₅₀ = 3.5 nM). Used in studies of reward systems and additions.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Perry, C., et al., 2013. Behav. Neurosci.127, 535.Burkett, J. et al. 2011. Neuropsychopharm.36, 2200.Steinmiller, L., et al., 2008. Psychopharmacol. (Berl).195, 497.Sterious, S., et al., 2003. J. Pharmacol. Exp. Ther.304, 301.Abbruscato, T., et al. 1997. J. Pharmacol.280, 402.

Packaging

1 mg in Glass bottle

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sequence

D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 (2-7 disulfide bond)

Warning

Toxicity: Standard Handling (A)