ICI 118551 Hydrochloride

Biochem/physiol Actions

Target K_i: 1.2, 120 and 257 nM for →2, →1 and →3 receptors respectively.

Reversible: yes

Primary Target→2 adrenergic receptors

General description

A highly selective antagonist for the β2 adrenergic receptors. Binds to the β2 subtype with at least 100 times greater affinity than β1 or β3, the two other known subtypes of the beta adrenoceptor. (K_i values are 1.2, 120 and 257 nM for β2, β1 and β3 receptors respectively).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Bilski, A., et al. 1983. J. Cardiovasc. Pharmacol.5, 430.Cook, S. et al. 1993. Br. J .Pharmacol.109, 1140.Ten Berge, R., et al. 1995. Eur. J. Pharmacol.275, 199.Strosberg, A., et al. 1996. TiPS17, 373.

Packaging

10 mg in Glass bottle

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)