Biochem/physiol Actions
Primary TargetnAChR
Reversible: yes
General description
A potent, nonselective, and noncompetitive antagonist of nAChRs (IC50 = 640 nM, 2.5 µM, 3.6 µM and 6.9 µM for α3β4, α4β2, α3β2 and α7 subtype nAChRs, respectively). Biologically viable admitted orally or systematically. Widely used in investigating the roles of central nAChRs in the brain functions (learning and memory, decision making, cognition) and disorders (addiction, Autisms, Tourette′s syndrome, Schizophrenia and various cognitive and mood disorders).
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Harris, C., et al. 2013. Psychopharmacol.225, 291.Lima, H., et al. 2013. Learning & Memory20, 120.Arnold, E., et al. 2012. J. Child Adolesc. Psychopharmacol.22, 198.Bacher, I., et al. 2009. Expert Opin. Pharmacother.10, 2709.Lippiello, M., et al. 2008. CNS Neurosci. Ther.14, 266.br>J. M. Young et al. 2001. Clin. Ther.23, 532.
Packaging
10 mg in Glass bottle
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Warning
Toxicity: Toxic (F)
This product has met the following criteria to qualify for the following awards: