General description

A cell-permeable morpholino-benzodioxol compound that inhibits MIF tautomerase activity (K_i and IC₅₀ = 0.57 and 2.4 µM, respectively) via direct non-covalent MIF interaction (K_D = 24.5 µM). RDR 03758 at 10 µM is shown to completely neutralize the overriding effect of 100 ng/ml MIF on the inhibition of LPS-stimulated TNF production by dexamethasone (Cat. No. 265005) in RAW 264.7 marcophage cultures.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Ouertatani-Sakouhi, H., et al. 2010. J. Biol. Chem.285, 26581.

Packaging

Packaged under inert gas

10 mg in Glass bottle

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Warning

Toxicity: Standard Handling (A)