Mifepristone

Biochem/physiol Actions

Reversible: no

Primary TargetProgesterone and glucocorticoid receptors

Product does not compete with ATP.

Cell permeable: yes

General description

A cell-permeable, synthetic steroid that acts as a potent antagonist of progesterone and glucocorticoid receptors. Reported to inhibit P-glycoprotein (P-gp) function and down-modulate P-gp mediated drug resistance. Also displays anti-angiogenic effects and suppresses vascular endothelial growth factor (VEGF) production. Shown to regulate the expression of Fas and FasL in mouse endometrium and of TRAIL in prostate cancer cells. As an antioxidant, it is reported to offer neuroprotection against controlled cortical impact (CCI) in CA1 pyramidal cells, as well as Aβ-, H₂O₂-, and glutamate-induced injury to mouse hippocampal HT22 cells.

A cell-permeable synthetic steroid that acts as a potent antagonist of progesterone and glucocorticoid receptors. Inhibits P-glycoprotein (P-gp) function and down-modulates P-gp mediated drug resistance. Displays anti-angiogenic effects and suppresses vascular endothelial growth factor (VEGF) production. Regulates the expression of Fas and FasL in mouse endometrium and TRAIL in prostate cancer cells. As an antioxidant, it offers neuroprotection against controlled cortical impact (CCI) in CA1 pyramidal cells, as well as Aβ-, H₂O₂-, and glutamate-induced injury to mouse hippocampal HT22 cells.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

McCullers, D.L., et al. 2002. Neuroscience109, 219.Sidell, N., et al. 2002. Ann. N. Y. Acad. Sci.955, 159.Gao, F., et al. 2001. Acta Pharmacol. Sin.22, 524.Hyder, S.M., et al. 2001. Int. J. Cancer92, 469.Lam, F.C., et al. 2001. J. Neurochem. 76, 1121.Sridhar, S., et al. 2001. Cancer Res.61, 7179.Behl, C., et al. 1997. Eur. J. Neurosci.9, 912.Greb, R.R., et al. 1997. Hum. Reprod.12, 1280.Gruol, D.J., et al. 1994. Cancer Res.54, 3088.

Packaging

Packaged under inert gas

50 mg in Plastic ampoule

Reconstitution

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Carcinogenic / Teratogenic (D)