MMP-13 Inhibitor

Biochem/physiol Actions

Cell permeable: no

Reversible: no

Primary TargetMMP-13 activity

Product does not compete with ATP.

Target IC₅₀: 8 nM against MMP-13

General description

A pyrimidine dicarboxamide compound that potently inhibits MMP-13 activity (IC₅₀ = 8 nM) with expected selectivity over MMP-1, -2, -3, -7, -8, -9, -10, -12, -14 and -16 as determined by conformational structure analysis. Shown to bind to the MMP-13 catalytic domain and act as a non-zinc-chelating inhibitor.

A potent inhibitor of MMP-13 activity (IC₅₀ = 8 nM) with expected selectivity over MMP-1, -2, -3, -7, -8, -9, -10, -12, -14 and -16 as determined by conformational structure analysis. Shown to bind to the MMP-13 catalytic domain and act as a non-zinc-chelating inhibitor.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Engel, C.K., et al. 2005. Chem. Biol.12, 181.

Packaging

1 mg in Plastic ampoule

Packaged under inert gas

Preparation Note

Further dilute in buffer immediately prior to use.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Warning

Toxicity: Standard Handling (A)