GM Indomethacin 1PC x 10GM

Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Cell permeable: yes

General description

A cell-permeable, non-steroidal anti-inflammatory, anti-pyretic agent. Non-selective cyclooxygenase (COX) inhibitor (IC₅₀ = 740 nM for COX-1; IC₅₀ = 970 nM for COX-2). Inhibits phospholipase A₂ (IC₅₀ = 145 µM). Reported to reduce Aβ₄₂ levels independently of COX activity.

A non-steroidal anti-inflammatory, cell permeable, antipyretic agent. Non-selective COX inhibitor (IC₅₀ = 740 nM for COX-1; IC₅₀ = 970 nM for COX-2). Inhibits phospholipase A₂ (IC₅₀ = 145 µM). Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation and suppresses production of Aβ-peptide and secreted form of APP by inhibition of APP mRNA levels in NG108-15 cells.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Kodoyama, K., et al. 2001. Biochem. Biophys. Res. Commun.281, 483.Weggen, S., et al. 2001. Nature414, 212.Kalgutkar, A.S., et al. 2000. Proc. Natl. Acad. Sci. USA97, 925.Klabunde, T., et al. 2000. Nat. Struct. Biol.7, 312.Futaki, N., et al. 1994. Prostaglandins47, 55.Futaki, N., et al. 1994. Prostaglandins47, 55.Stevenson, K.M., and Lumbers, E.R. 1992. J. Dev. Physiol. 17, 257.Oliw, E. 1980. Prostaglandins19, 271.

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Packaging

10 g in Alu drum

Warning

Toxicity: Highly Toxic & Carcinogenic / Teratogenic (I)