Biochem/physiol Actions
Reversible: no
Product does not compete with ATP.
Primary Targetcaspase-1
Cell permeable: yes
General description
A highly selective, competitive, cell-permeable, and irreversible inhibitor of caspase-1, caspase-4, and caspase-5. Inactivates the enzyme with a rate limited by diffusion and is relatively inert toward other bionucleophiles such as glutathione, making it an excellent candidate for in vivo studies of enzyme inhibition.
Highly selective, competitive and irreversible inhibitor of caspase-1 and caspase-5. Inactivates the enzyme with a rate limited by diffusion and is relatively inert toward other bionucleophiles, such as glutathione, making it an excellent candidate for in vivo studies of enzyme inhibition.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.Thornberry, N.A., et al. 1994. Biochemistry 33, 3934.
Packaging
1 mg in Plastic ampoule
Reconstitution
Following recosntitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Sequence
Ac-Tyr-Val-Ala-Asp-AOM (AOM = 2,6-dimethylbenzoyloxymethyl ketone)
Warning
Toxicity: Standard Handling (A)
This product has met the following criteria to qualify for the following awards: