Biochem/physiol Actions
Reversible: yes
Target IC50: 18 nM for GSK-3&beta
Cell permeable: yes
Primary TargetGSK-3β
General description
A Kenpaullone (>Cat. No. 422000) analog that acts as a potent and ATP-competitive inhibitor of GSK-3β (IC50 = 18 nM). Displays over 100-fold greater selectivity over Cdk1/cyclin B and Cdk5/p25 (IC50 = 2.0 µM and 4.2 µM, respectively). The solid form of this compound (Cat. No. 191500) is also available.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Kunick, C., et al. 2004. Bioorg. Med. Chem. Lett.14, 413.
Packaging
500 µg in Glass bottle
Packaged under inert gas
Physical form
A 10 mM (500 µg/152 µL) solution of 1-Azakenpaullone (Cat. No. 191500) in DMSO.
Reconstitution
Following initial thaw, aliquot and freeze. Aliquots are stable for up to 6 months at -20°C.
Warning
Toxicity: Irritant (B)
This product has met the following criteria to qualify for the following awards: