InSolution 1-Azakenpaullone

Code: 191501-500UG D2-231

Biochem/physiol Actions

Reversible: yes

Target IC50: 18 nM for GSK-3&beta

Cell permeable: yes

Primary TargetGSK-3β

General des...


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€121.67 500UG
Discontinued
€149.65 inc. VAT

Biochem/physiol Actions

Reversible: yes

Target IC50: 18 nM for GSK-3&beta

Cell permeable: yes

Primary TargetGSK-3β

General description

A Kenpaullone (>Cat. No. 422000) analog that acts as a potent and ATP-competitive inhibitor of GSK-3β (IC50 = 18 nM). Displays over 100-fold greater selectivity over Cdk1/cyclin B and Cdk5/p25 (IC50 = 2.0 µM and 4.2 µM, respectively). The solid form of this compound (Cat. No. 191500) is also available.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Kunick, C., et al. 2004. Bioorg. Med. Chem. Lett.14, 413.

Packaging

500 µg in Glass bottle

Packaged under inert gas

Physical form

A 10 mM (500 µg/152 µL) solution of 1-Azakenpaullone (Cat. No. 191500) in DMSO.

Reconstitution

Following initial thaw, aliquot and freeze. Aliquots are stable for up to 6 months at -20°C.

Warning

Toxicity: Irritant (B)

assay≥94% (HPLC)
formliquid
manufacturer/tradenameCalbiochem®
Quality Level100
shipped indry ice
storage conditiondesiccated (hygroscopic), protect from light, OK to freeze
storage temp.−20°C
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