Biochem/physiol Actions

Reversible: yes

Target IC₅₀: 18 nM for GSK-3&beta

Cell permeable: yes

Primary TargetGSK-3β

General description

A Kenpaullone (>Cat. No. 422000) analog that acts as a potent and ATP-competitive inhibitor of GSK-3β (IC₅₀ = 18 nM). Displays over 100-fold greater selectivity over Cdk1/cyclin B and Cdk5/p25 (IC₅₀ = 2.0 µM and 4.2 µM, respectively). The solid form of this compound (Cat. No. 191500) is also available.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Kunick, C., et al. 2004. Bioorg. Med. Chem. Lett.14, 413.

Packaging

500 µg in Glass bottle

Packaged under inert gas

Physical form

A 10 mM (500 µg/152 µL) solution of 1-Azakenpaullone (Cat. No. 191500) in DMSO.

Reconstitution

Following initial thaw, aliquot and freeze. Aliquots are stable for up to 6 months at -20°C.

Warning

Toxicity: Irritant (B)