InSolution Akt Inhibitor IV

Biochem/physiol Actions

Target IC₅₀: 625 nM and ﹤1.25 µM in blocking Akt-mediated FOXO1a nuclear export and cell proliferation, respectively, in 786-O cells

Reversible: yes

Product does not compete with ATP.

Primary TargetAkt

Cell permeable: yes

General description

A cell-permeable benzimidazole compound that inhibits Akt phosphorylation/activation presumably by targeting the ATP binding site of a kinase upstream of Akt, but downstream of PI3K. Shown to block Akt-mediated FOXO1a nuclear export (IC_{50﹤/sub> = 625 nM) and cell proliferation (IC50﹤/sub><1.25 µM) in 786-O cells. Unlike phosphatidylinositol analog-based Akt inhibitors (Cat. Nos. 124005, 124008, 124009), this inhibitor does not affect PI3K.}

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Packaging

1 mg in Plastic ampoule

Packaged under inert gas

Please refer to vial label for lot-specific concentration.

Physical form

A 10 mM (1 mg/163 µl) solution of Akt Inhibitor IV (Cat. No. 124011) in DMSO.

Reconstitution

Following initial use, aliquot and refrigerate (4°C).

Warning

Toxicity: Irritant (B)