Acidic Mammalian Chitinase Inhibitor; Bisdionin F

General description

A cell-permeable, competitive Acidic Mammalian Chitinase (AMCase) Inhibitor (IC₅₀ = 0.92 µM and K_i = 0.42 µM for hAMCase, and IC₅₀= 2.2 µM for mAMCase, in vitro) that demonstrates 20-fold selectivity for hAMCase over hCHIT1. It is shown to decrease chitinase enzymatic activity (5 mg/kg, i.p.) in the lungs of control PBS- and OVA-challenged mice. Furthermore, it attenuates lung chitinase activity, reduces eosinophil influx, and improves ventilatory function, in vivo, in a murine model of allergic inflammation. It also causes neutrophilia in the lungs of OVA-challenged mice.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Sutherland, T.E., et al. 2011. Chem. Biol.18, 569.

Packaging

5 mg in Glass bottle

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)