Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Primary TargetInduces the release of nitric oxide

General description

Induces the release of nitric oxide. Other physiological functions include stimulation of pain receptors, inhibition of cAMP accumulation, and induction of smooth muscle contraction and vasodilation. Also involved in edema resulting from trauma or injury. Improves post-ischemic recovery of heart via a nitric oxide-dependent mechanism.

Induces the release of nitric oxide. Other physiological functions include stimulation of pain receptors, inhibition of cAMP accumulation, induction of smooth muscle contraction, and vasodilation. Also involved in edema resulting from trauma or injury. Improves post-ischemic recovery of heart via a nitric oxide-dependent mechanism.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Mombouli, J.V., and Vanhoutte, P.M. 1995. Am. J. Hypertens.8, 195.Zhu, P., et al. 1995. Cardiovasc. Res.29, 658.Bedarida, G.V., et al. 1994. Horm. Metab. Res. 26, 109.Altiok, N., and Fredholm, B.B. 1993. Cell Signal. 5, 279.

Packaging

Yes

Physical form

Supplied as an acetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sequence

H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH