Interleukin 21 (IL-21) is a cytokine produced by natural killer (NK) cells and some T cells. IL-21 has broad immunological functions and can regulate NK cells, macrophages, and dendritic cells, as well as playing a role in promoting B cell and antibody responses. Recombinant IL-21 can be used in the differentiation of subsets T cells, NK cells, B cells and plasma cells. Qkine recombinant human IL-21 is a pure and highly bioactive 15.3kDa monomer.
- High purity human protein (Uniprot: Q9HBE4)
- 15.3kDa (monomer)
- ﹥98%, by SDS-PAGE quantitative densitometry
- Expressed in E. coli
- Animal origin-free (AOF) and carrier protein-free
- Manufactured in Cambridge, UK laboratories
- Lyophilised from acetonitrile
- Resuspend in 10mM HCl (reconstitution solution A) at ﹥50µg/mL, add carrier protein if desired, prepare single-use aliquots and store frozen at -20°C (short-term) or -80°C (long-term)
- Featured applications: stimulation of activated T cell proliferation, development, survival, and function of T cells, activation of T-cells and natural killer (NK) cells, differentiation of B cells into plasma cells, stimulation of activated B cell proliferation, development and formation of B cells
- Alternative names: IL21, Interleukin 21, IL-21, Za11, Interleukin-21, CVID11, IL-21
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