1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one, powder

Code: O3636-25MG D2-231

Application

1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one has been used as a oxidising agent for affinity selection-mass spectrometry (AS-MS) compound binding assay, as a solub...


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Your Price
€517.43 25MG
Discontinued
€636.44 inc. VAT

Application

1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one has been used as a oxidising agent for affinity selection-mass spectrometry (AS-MS) compound binding assay, as a soluble guanylate cyclase (sGC) inhibitor to inhibit S-nitroso-N-acetyl-DL-penicillamine (SNAP)-induced cGMP production.

Biochem/physiol Actions

H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) non competitively inhibits the action of nitric oxide-sensitive guanylyl cyclase and results in a supposedly irreversible oxidation of the prosthetic heme group. ODQ has been used to study the role of cyclic guanosine monophosphate (cGMP) pathway in nitric oxide (NO) signal transduction.

Selective inhibitor of nitric oxide-sensitive guanylyl cyclase.

Caution

Hygroscopic

Packaging

5, 25 mg in glass bottle

assay≥98% (TLC)
colorpale yellow
formpowder
Gene Informationhuman ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)
InChI keyLZMHWZHOZLVYDL-UHFFFAOYSA-N
InChI1S/C9H5N3O2/c13-9-12-7-4-2-1-3-6(7)10-5-8(12)11-14-9/h1-5H
Quality Level200
SMILES stringO=C1ON=C2C=Nc3ccccc3N12
solubilityethanol: 1.2 mg/mL, H2O: insoluble, DMSO: 5 mg/mL
storage temp.2-8°C
Cas Number41443-28-1
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