Biochem/physiol Actions

PAK4 (p21 protein (Cdc42/Rac)-activated kinase 4) belongs to the group 2 PAKs, which also include PAK5 and PAK6. Unlike other PAK proteins, PAK4 has strong association with CDC42 (cell division cycle 42) but has weak interaction with RAC (AKT1, v-akt murine thymoma viral oncogene homolog 1). It is a connection between CDC42 and filopodium formation. It regulates CDC42-induced anchorage-independent growth.

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Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.