Analysis Note

Colour (visual): white to slight yellow to beigeAppearance of substance (visual): powderIdentity (IR): passes testEnantiomeric purity: ≥ 99.5 % (a/a)Purity (TLC(011A)): ≥ 98 %Assay (HPLC, area%): ≥ 99.0 % (a/a)Solubility (1 mmole in 2 ml DMF): clearly solubleFor TLC-Systems see our General Catalog

General description

A building block for the intoduction of thiaproline (Thz) during Fmoc SPPS. Thz has been employed as a masked cysteine residue to prevent self-ligation during native chemical ligation reactions (NCL) of peptide thioesters bearing an N-terminal Cys residue [6]. Once ligation is complete, the N-terminal Cys residue of the resultant peptide is unmasked by ring opening the Thz residue by treatment with methoxyamine, thereby enabling its subsequent ligation to another peptide thioester fragment.

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