Analysis Note

Color (visual): white to slight yellow to beigeAppearance of substance (visual): powderIdentity (IR): passes testPurity (TLC(157A)): ≥ 98 %Purity (TLC(0811)): ≥ 98 %Enantiomeric purity: ≥ 99.5 % (a/a)Assay (HPLC, area%): ≥ 98.0 % (a/a)Solubility (1 mmole in 2 ml DMF): clearly solubleAssay (acidimetric): ≥ 95.0 %Water (K. F.): ≤ 2.0 %For TLC-Systems see our General Catalog

General description

The side-chain Trt group can be selectively removed with 1% TFA in DCM containing 5% TIS [1, 2] or 20% dichloroacetic acid in DCM [3], enabling the side-chain hydroxyl group to be selectively modified whilst the derivative is attached to the solid support. This is an excellent derivative for the synthesis of phosphoserine containing peptides and peptides modified at the serine side-chain [1]. The use of trityl protected amino acids was shown to result in purer products than when standard t-Bu protected amino acids were utilized [2, 4].

The product number for this product was previously 04-12-1092.

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Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Linkage

Replaces: 04-12-1092